Anti-inflammatory and Atheroprotective Properties of Omega-3 Polyunsaturated Fatty Acids
نویسندگان
چکیده
Atherosclerosis prevention and treatment remain of great concern in the field of cardiovascular medicine. Altering inflammatory component of atherogenesis has been hypothesized to be beneficial, and thus searching for new antiinflammatory compounds for cardiovascular disease is warranted. Recent discovery of new lipid mediators, which are generated from essential omega-3 fatty acids, represent a promising new area of investigation. These bioactive compounds, termed specialized pro-resolving lipid mediators (SPMs), have immunomodulatory and potent resolution effects. Moreover, cyclooxygenases inhibitors, such as acetylsalicylic acid, besides blocking eicosanoids production also trigger the biosynthesis of specific epimers of these SPMs. However, it has not been determined whether aspirin interacts synergistically with omega-3 fatty acids to affect atherosclerosis. The described antiinflammatory and atheroprotective mechanisms of omega-3 fatty acids and aspirin could help in improving the treatment not just for cardiovascular but some of other inflammatory conditions.
منابع مشابه
The effect of omega- 3 polyunsaturated fatty acids on endothelial tight junction occludin expression in rat aorta during lipopolysaccharide-induced inflammation
Objective(s): Occludin is essential for proper assembly of tight junctions (TJs) which regulate paracellular endothelial permeability. Omega-3 polyunsaturated fatty acids (Ω-3 PUFA) protect endothelial barrier function against injury. Materials and Methods: We examined anti-inflammatory effect of Ω-3 PUFA intake (30 mg/kg/day for 10 days) on expression and location of occludin in the aorta of ...
متن کاملEvaluation of the Relationship between Endometriosis and Omega-3 and Omega-6 Polyunsaturated Fatty Acids
Background: Endometriosis is a common chronic inflammation causing major problems including infertility. The role of omega-3 and omega-6 fatty acids as their potential anti-inflammatory effects in endometriosis needs to be further explored. The objective of this study was to compare serum phospholipid fatty acid profile in endometriosis patients with controls, and to explore the correlation of ...
متن کاملP 81: Omega-3 Fatty Acid and Oxylipins in Management of Alzheimer Disease
Neurodegenerative disease are characterized by the progressive loss of neurons from specific origins of the CNS .Alzheimer disease (AD) is a neurodegenerative disorder which affect brain regains that control memory and ability to learn. It is estimated that 27 million people are affected word wide and this number is expected to triple by 2050 due to increase of the population life expectancy. A...
متن کاملProduction of Protein-Polysaccharide Fibers Containing Omega-3 Fatty Acids Using Electrospinning Method and Determination of Optimal Process Conditions with Response Surface Methodology
Background and Objectives: Omega-3 fatty acids are very important in the human diet for the prevention of diseases. Materials & Methods: In the present study, the effect of whey protein concentrate (5, 6.67, 10, 13.33, 15%) and guar gum (0.1, 0.25, 0.55, 0.85, 1%) were evaluated on the qualitative properties of fish oil emulsion and electrospun fibers. Results: Increasing concentration of whey...
متن کاملOmega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions.
BACKGROUND AND PURPOSE Current available therapies for neonatal hypoxia/ischemia (H/I) brain injury are rather limited. Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H/I in neonates. METHODS Female rats were treated with or without an omega-3 polyunsaturated fatty acids-enriched diet from the second day of pre...
متن کامل